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KMID : 0043320050280121345
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Archives of Pharmacal Research
2005 Volume.28 No. 12 p.1345 ~ p.1349
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Phenolic Constituents with Inhibitory Activity against NFAT Transcription from Desmos chinensis
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Kiem Phan Van
Minh Chau Van
Huang Hoang Thanh
Lee Jung-Joon
Lee Im-Seon
Kim Young-Ho
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Abstract
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Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2’,3’-dihydroxy-4’,6’dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. Of these constituents, compounds 2 (: 3.89 0.39 M) and 3 (: 9.77 0.26 M) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 (: 28.4 2.62 M) exhibited moderate inhibitory activity.
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KEYWORD
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Desmos chinensis, NFAT Transcription factor, Phenolic constituents
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